Total Protein Test – Serum Total Protein

The Total Protein Test is a blood test that measures the combined concentration of two major protein groups: albumin and globulins. These proteins play important roles in maintaining fluid balance, transporting substances, and supporting immune function.

The test is commonly performed as part of a liver function assessment or general biochemical investigation.

What Does the Total Protein Test Measure?

• Albumin: The main protein produced by the liver. It helps maintain fluid balance and transports various substances in the blood.
• Globulins: A group of proteins that includes antibodies and proteins involved in immune function and transport.

Why Is a Total Protein Test Recommended?

Your healthcare professional may recommend this test to help:

• Assess blood protein levels
• Investigate possible liver-related conditions
• Support the evaluation of kidney disorders
• Investigate nutritional problems or protein loss
• Evaluate certain inflammatory or immune-related conditions

Sample Requirements

• Sample type: Blood, typically serum.
• Fasting: Usually not required for an isolated total protein test.
• Preparation: Follow any instructions provided by your healthcare professional, especially if other tests are being performed at the same time.

Understanding Your Results

High total protein levels may occur with dehydration, chronic inflammation, or certain immune-related conditions.

Low total protein levels may be associated with inadequate nutrition, liver disease, kidney-related protein loss, or other medical conditions.

Total protein results should be interpreted alongside albumin, globulin levels, the albumin-to-globulin ratio (A/G ratio), and other relevant investigations when indicated.

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